I also use Advanced Scene Switcher (aka AdvSS, for short) for the exact functionality
@AaronD mentioned - the change of a scene when a media file ends playing. I use that same plugin to handle my ending sequence (using multiple scenes, with a fade-to black feature). Using AdvSS, I also automated the start of recording (as I use Facebook's Scheduled Event feature, so one must stream before the start time, so I set a Scene change to a specific scene at a specific time to start recording, then go to a Countdown scene, to a standard intro video, then to my actual fist 'Live' content scene. The last scene in my ending sequence also triggers an end of Streaming and Recording
If not clear in the above, going from OBS Scene #1 (Intro) to Scene #2 (normal content) by default means clicking on the desired Scene (#2 in this case) using Keyboard or mouse (and I only use the mouse for this). If I accidentally click a Scene I don't want - too bad, OBS does as instructed [Hence my use of the AdvSS plugin, to automate as much as was practical for me].
And the Scene order in OBS doesn't really have a meaning. I do standard top to bottom as a sequence, but I also have a couple of scenes where I vary the camera vs screen content. I select between those scenes as appropriate. As my text content is in a PowerPoint slide show, I could use the Macro functionality in PowerPoint to send commands to OBS (using websockets) to change OBS scene, or whatever, as I advance slides. In my workflow, someone else creates the slides, and is not the type of person to be attentive to a hidden detail like macro settings, so for now, I do the Scene changes manually. I mention this as there are ways to let your content be pre-setup to trigger actions in OBS (but depends on source 'program' and actual material)... just food for thought
As for using OBS when blind.... yes, a true challenge, as many features essentially assume a sighted person making real time selections (like Scenes). This is NOT my use case, so don't consider me authoritative on this, but I'd suspect using something like a Streamdeck would come in handy, where specific buttons on the panel could be associated with Scene selections, or other OBS actions. I'm assuming using a mouse to select a specific item on scene is a challenge (for visually impaired) to near impossible to do quickly (if at all??) for a completely blind person. I further assume that fixed position button would be MUCH easier. One option is to configure OBS Hot Keys to map specific keyboard key combinations to a specific action, another common options I'd think would be a streamdeck, or similar.
Other side note - Regarding
@Suslik V comment above about Studio Mode. Beware that Studio Mode involves 2X the rendering, and unlikely to be of use to someone blind. Regardless, if a PC gets overloaded with the computationally demanding workload of real-time video encoding, recognize turning Studio Mode off might be one way to help reduce workload on computer
Good Luck