My settings are very standard. I use 3500/3500 bit rate, quality 10, CFR enabled, CBR disabled, 1280x720 base resolution with no downscale, faster preset, multi-threaded optimizations enabled, higher quality resampling enabled, no force audio to sync to video time, no minimize network impact...I think that's it.
On 0.472 this gives me 3-4 seconds of delay on my RTMP server.