Again, does this come out of just the stream, or your headset/speakers as well? Could you post a vod? And a log? This can happen sometimes with OBS simply because OBS activates many more devices than most other programs. Encoding, graphics, sound capture from multiple devices, video device capture. All these things combined can sometimes cause interference to come through where it otherwise wouldn't.
There are a number of ways to fix/reduce the issue:
- Reduce webcam resolution. This has been known to help (reduces motherboard bandwidth usage)
- Changing the ports of your USB device(s) has also been known to help
- Turning down encoder settings has helped in rare circumstances