Of course the less editing is done, the better the audio quality. If you apply filters without knowing what they exactly do, you might introduce new issues, and you might look for other filters to correct that (without knowing this is an issue from the first filter), and in the end you do much filtering but only to filter issues of your filters.
These are a few topics about audio:
- to remove low volume noise while you are not speaking, use the noise gate on your mic source
- to duck an audio source while you speak (lower the volume of game audio while you speak), use the "Sidechain/Ducking source" option of the Compressor filter applied on the game audio source and set the mic source in the "Sidechain/Ducking source" option.
- if you're unable to speak with a constant voice, use the compressor filter on your mic source to amplify the parts with a low voice
- to make the signal use the complete volume range, use the expander filter on your mic source
- to avoid clipping of loud parts, use the limiter filter on your mic source
- the usual sequence is noise filter (only required with noisy microphones) -> noise gate -> compressor -> expander -> limiter
See also:
https://electricfiddler.com/compressors-limiters-noise-gates-expanders/
Now I mentioned all the filters, but don't just insert them mindlessly in your sources. Work out the effects of each of them, and if you're unable to hear a difference, don't use that particular filter. If your mic doesn't produce noise, don't use the noise filter. If you speak constantly with never being too low, you don't need a compressor. If you don't shout, you don't need a limiter. If you don't hear a difference with or without an expander, don't use an expander.