The video quality will not be better compared to lossless compression (hence it's called lossless - no loss in quality). A bit of compression is still desired as you otherwise will face issues with saving those massive to a drive. Lossless is already hard to store (e.g. UTVIDEO codec). 1080p60 is already something around 300-500 mbit/s with modern lossless codecs like utvideo that is included with OBS.
Saving uncompressed 8-bit RGB is not reasonably storable for consumer hardware.
For example, a 1-Minute clip of 1080p at 60 fps will result in 373 Mbyte per second. That's a 1.34 Terabyte file for only one minute.
TL;DR: don't do uncompressed. Use modern lossless codecs (utvideo, huffyuv, zlib etc.)