@Fenrir I had the same problem today with the same "en-us.ini" "failed to find".
I was using OBS with no problems. I closed it and worked on some other things for a while, when I tried to open it no more than an hour later it would not open without crashing immediately
I have tried deleting and re-instaling OBS, restarting my computer. And I didn't change anything on my computer that should have affected it. Unless something updated in the background. I don't use any plug-ins.
I read something about changing the scenes.json folder in order to fix the problem, but I am not very familiar with altering code.
I could post error log. I am running OS X 10.12.3 MBpro