I never thought about streaming, in that regard yes lossless is academic curiosity, but on semi-professional level (ie, serious youtube channels, etc), and of course professional ones lossless is always used as intermediary files for local encoding, which is what I do encoding gameplays. Otherwise you would end with (h.264 footage->h.264 edited/effects->h.264 youtube) which IMO is crap, but some people don't even know/care.
Besides that, if you record a snes or nes game with 4:2:0 planes it is very easy to see image degradation, pair this with the above 3 or 4 times transcoding and you will find why true lossless (which implies no chroma subsampling) is so much needed.
I also own a 750Ti, I don't know how you did the test but 444 or not lossless encoding is not so demanding as lossy ones, there aren't as many optimizations to be done, so it kind of compensates.
I didn't know OBS was streaming focused software so sorry about that, maybe there are more nvenc encoding programs around?