00:44:15.833: Output 'simple_stream': Total encoded frames: 509483
00:44:15.833: Output 'simple_stream': Total drawn frames: 519163
00:44:15.833: Output 'simple_stream': Number of lagged frames due to rendering lag/stalls: 7432 (1.4%)
00:44:15.833: Output 'simple_stream': Number of dropped frames due to insufficient bandwidth/connection stalls: 9351 (1.8%)
00:44:15.890: [rtmp stream: 'simple_stream'] Freeing 62 remaining packets
00:44:16.476: Video stopped, number of skipped frames due to encoding lag: 46741/513813 (9.1%)
Lagged frames are the ones caused by the GPU not keeping up, 1.4%.
Dropped frames are the ones due to your internet connection being flaky, 1.8%
Skipped frames are the ones due to your CPU not keeping up, 9.1%.
The first thing I'd do is downscale the webcam more, from 720p down to 480p. You don't need it that high rez anyways when its just a postage stamp on your overall stream. And it can have an impact on performance.
The next thing I'd do is change the downscale to one of the other options other than Lanczos. Lanczos is the most CPU intensive and in the past people didn't think it looked better than the others.
If none of those fix it (you want the percentages to be less than 1% for the video to look good), then switch the preset to SuperFast from VeryFast.
This probably won't fix the internet-related Dropped Frames though. You might need to yell at your ISP, or decrease your bitrate, or tell everyone sharing your connection to stop torrenting, or something along those lines, to fix that.