Why would a check/uncheck button to activate/deactivate the hotkeys be useful at all? That would require you to go into the settings and change things for no reason.
I'm guessing you've never used a keyboard or any other software that has hotkeys.
The whole point of hotkeys, is so you can set buttons you don't use much as a "toggle/button" to do something.
There would be no point of having a button, checkbox or anything like that, that would disable the hotkeys.
Just set your hotkeys to keys you don't ever use, like half of the "F Keys" and about 20 other buttons that I can think of on a standard size keyboard that 99% of people don't use while streaming.